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Rossjohn J, McKinstry WJ, Oakley AJ, Verger D, Flanagan J, Chelvanayagam G

The open-label design meant both patients and physicians knew which medication was being used

124 Within heterogeneous tumor populations, preexisting or newly acquired genetic and epigenetic alterations confer survival advantages to specific subclones, which expand during treatment

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They found marked alterations in the microbiome of smokers, as well as microbial metabolite changes that were similar to those found in the mouse smokers, including increased levels of DMG and its intermediate products