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Recent advancements in drug delivery systems, combination therapies, and nanotechnology, including plant-derived carbon dots, offer promising strategies to enhance L-DOPAs effectiveness while mitigating its limitations
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3.3.5.2 Probiotics In mice model of humid heatinduced anxiety, oral administration of probiotic Lactobacillus murinus for 14 days significantly reduced anxiety-like behaviors by restoring gut microbiota composition, which further downregulated neuroinflammatory markers (Weng et al., 2024)
A May 2025 study in Molecular Therapy from the INc-UAB showed that gene therapy increasing secreted klotho (s-KL) in mice extended lifespan by 15-20% while improving muscle, bone, and cognitive health at 24 months of age (equivalent to ~70 human years)
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