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Both carry a boxed warning for thyroid C-cell tumors based on animal studies, and neither should be used in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

Thyroid hormones, estrogen, insulin, noradrenaline and prolactin are believed to play an important role in cellulite production

By moving gradually from 2 mg to higher doses, the trial sponsors could keep dropout rates low while still pushing toward therapeutically meaningful levels

Retatrutide and orforglipron are furthest along in testing, while survodutide may take longer