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It is about getting rid of the complexity of the venom, and trying to home in on that very specific thing that does what you want.' A breakthrough discovery found that a hormone in the lizard's saliva, exendin-4, could be used to treat type 2 diabetes
16,170 Views 409 Download 7 Web of Science 6 Crossref 6 Scopus Abstract The components of the endogenous cannabinoid system are widely expressed in the gastrointestinal tract contributing to local homeostasis
The 5- and 10-year survival probabilities in this matched obesity cohort favored GLP-1 receptor agonist users, and the authors interpreted these data as suggesting a potentially meaningful long-term association between GLP-1 receptor agonist exposure and improved outcomes in this group
10.1111/and.14204 5
The nuclear respiratory factors (Nrf1 and Nrf2) that initiate the transcription of genes linked to mitochondrial biogenesis are co-activated by SIRT1 through the activation and deacetylation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1) (Scarpulla, 2011), a master regulator of mitochondrial biogenesis
