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(Growth Hormone and IGF Research, 2003) reviewed peptide therapy approaches targeting the somatotropic axis and documented measurable shifts in body composition in subjects with growth hormone deficiency, including reductions in adipose tissue, improvements in lean muscle mass, positive changes in bone mineral parameters, and favorable metabolic marker changes
Moreover, reports are inconsistent, indicating that BMIs, fasting insulin, and free testosterone levels decreased in some meta-analyses, but in other studies, there were no substantial changes in BMI or insulin resistance
Metformin, one of the medicines in XIGDUO XR, can cause a rare but serious condition called lactic acidosis (a build-up of an acid in the blood) that can cause death
Hormonal changes such as shifts in IGF-1, cortisol, or appetite levels can occur depending on the peptide
The worry is real for one group
