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However, in conditions such as AD or PD, where activation is prolonged or chronic, astrocytes may undergo irreversible changes, contributing to neuroinflammation and scarring through the non-cell-autonomous pathways 20

SOD activity was measured in a reaction mixture containing 50 mM phosphate buffer (pH 7.8), 0.1 mM EDTA, 13 mM methionine, 75 M nitroblue tetrazolium (NBT), 2 M riboflavin, and 50 l enzyme aliquot 51