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The pathways of mitophagy for quality control and clearance of mitochondria
Consequently, an extracellular cystine or intracellular cysteine deficiency or inhibition of system ( SLC7A11 ) would reduce the GSH level, inhibit GSH-dependent GPX4 activity, and lead to the intracellular accumulation of L-ROS and cell death (Dolma et al., 2003
et al (2020) SI Appendix for: Integrating smFRET, SAXS and NMR data to infer structural ensembles of an intrinsically-disordered protein
Meanwhile, Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC 50 s of 4.2 and 1.1 nM, respectively
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