A recent clinical study further confirmed that NSW disrupts 24-hour rhythms of PER2, PER3, BMAL1, and ESR2 in PBMCs, impairs the inverse correlation between PER2 and BMAL1, and alters PER1 and ESR1 expression patterns, highlighting a misalignment in the peripheral circadian network associated with NSW schedules 212
10.1038/nri2062 111 TanJ.XuX.TongZ.LinJ.YuQ.LinY.et al (2015)
Assessing Glutathione Demand At Elemental Health and Nutrition, assessment extends beyond thyroid-stimulating hormone (TSH) alone and includes functional testing to understand antioxidant demand and methylation capacity: Thyroid antibodies (TPO, TgAb): Indicators of immune activity against thyroid tissue and potential markers of oxidative stress burden
Instead, it bears the status of a research compound that can be legally obtained only by scientists and used for research
But the severity and duration vary enormously depending on how you titrate and what you eat