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Proton pump inhibitors reduce gastric acid production, which impairs the release of food-bound B12 but has less effect on synthetic B12 in supplements

Parry Strong A, Haeusler S, Weatherall M, Krebs J (2016) Sublingual vitamin B12 compared to intramuscular injection in patients with type 2 diabetes treated with metformin: a randomized trial

10.1016/S0149-2918(03)90096-8

Conclusion The combination of NAD+ and 5-Amino-1MQ is still relatively new, but its potential is groundbreaking

Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB