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Xc system is crucial in regulating ferroptosis and SLC7A11 facilitates the exchange of extracellular cystine and intracellular glutamate across the plasma membrane, as well as the reduction of cystine to cysteine within cells, which is essential for GSH production [75]

Overlap with retatrutide

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Additionally, ryanodine receptors (RYR), primarily associated with the endoplasmic reticulum and on the secretory vesicles, can amplify Ca 2+ signals and are involved in increasing the secretion of insulin when the channel is sensitized by the influx of messenger molecules (247, 248)

10.3389/fncel.2022.1025708 64 ChenJ.MarksE.LaiB.ZhangZ.DuceJ