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Among these, inflammation, oxidative str1ss and endoplasmic reticulum stress, alteration of adipokine secretion pattern (particularly reduction in secretion of insulin-sensitizing adipokines such as adiponectin, omentin, and vaspin) and hormones, reduced catabolism of branched-chain amino acids, and release of exosomes carrying microRNAs capable of interfering with insulin signaling [20, 21]

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Orellana AM, Mazucanti CH, dos Anjos LP, de S Lima L, Kawamoto EM, Scavone C (2023) Klotho increases antioxidant defenses in astrocytes and ubiquitinproteasome activity in neurons

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Pragmatic pathways often begin with metformin, then layer therapies by risk profile and A1C goals

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Synovial fluid and plasma selenium, copper, zinc, and iron concentrations in patients with rheumatoid arthritis and osteoarthritis

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