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For example, a single nucleotide polymorphism (SNP) (found in 31% of the Japanese population investigated within the referenced study) leads to an amino acid change in the OATP2B1 protein (S486F), which is associated with a greater than 50% reduction in transport capacity (Nozawa et al
[1] So the compound has good membrane-permeability characteristics on the bench, while the demonstrated biological activity in a whole animal was produced by injection
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