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In addition, they are costly medications, they are not always covered by insurance, and they generally need to be taken forever
Redox Signal 23 , 597612 (2015)
Starting doses are generally cheaper ($149-249/month) while maintenance doses at 1.7 mg or 2.4 mg can cost $199-499/month
The monitoring parameters of pharmacotherapy with a narrow index also warrant consideration (for example, concurrent warfarin may require closer international normalized ratio monitoring)
The FDA also recommends examining hard clinical endpoints such hepatic decompensations, transplant free survival, and all-cause mortality, although these results are not necessarily needed prior to drug approval given the long length of follow up potentially required
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