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It binds to GLP-1 receptors in pancreatic beta cells, enhancing glucose-dependent insulin secretion while simultaneously suppressing glucagon release from alpha cells

doi: 10.1097/j.pain.0000000000001939 92 AshburnMAStaatsPS

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The additional benefits for knee pain, fatty liver disease, and cardiovascular risk markers are meaningful

Some subjects experience declining response a Phase 2 trial found IGF-1 levels plateaued at month 6 despite continued daily MK-677 dosing, suggesting partial desensitization of the GH-IGF-1 axis under constant stimulation