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25-27 Furthermore, IC/BPS patients displaying widespread pain showed multiple indications of central neurobiological pain sensitization, correlating with quantitative sensory testing, fMRI (functional magnetic resonance imaging), and inflammatory markers
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An ensemble of the ten lowest energy structural models is shown in Fig
It is worth emphasizing that many of these reported effects may reflect the injection process itself, product impurities, or placebo/nocebo phenomena rather than a direct pharmacological action of the peptide
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