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The mutation of GLP-1 Phe 28 to Ala causes it to lose nearly all of its affinity (IC 50 : 0.27 nM357 nM), and Ile 29 mutation decreases the affinity notably (IC 50 : 0.27 nM25 nM), while Trp 31 , Leu 32 , and Val 33 mutations have little influence, showing that they may be merely subsidiary
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Moreover, researchers have proposed a bidirectional relationship
The protease activated protein C and parmodulin-2 were found to effectively counteract sustained tubular p21 expression and tubular senescence in both mouse proximal tubular cells and db/db mice (206)
Schieszer, J
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