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When to Seek Medical Advice About Medication Combinations Contact your GP or prescribing clinician before combining ibuprofen with Wegovy if you have : Kidney disease or impaired renal function NSAIDs can further compromise kidney performance History of peptic ulcers or gastrointestinal bleeding significantly increased risk with NSAID use Cardiovascular disease including heart failure, previous heart attack, or stroke Uncontrolled hypertension NSAIDs can elevate blood pressure Asthma some individuals experience NSAID-induced bronchospasm Liver disease affects metabolism of ibuprofen and paracetamol (semaglutide is not significantly affected by hepatic impairment) Taking anticoagulants warfarin (may require INR monitoring when starting semaglutide), DOACs, or antiplatelet agents increase bleeding risk with NSAIDs [2] Seek urgent medical attention if you experience : Severe abdominal pain particularly if sharp, persistent, or accompanied by vomiting Severe persistent upper abdominal pain radiating to the back potential sign of pancreatitis

Presented for research literature review only Kleber HP et al

Research into the wider effects of these medications on reward and motivation is still developing

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If you want the detailed conversion numbers, SeekPeptides maintains comprehensive dose conversion charts that map equivalent doses between the two medications