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They could have seen if score improvement (or other measures of pain/movement) improved prior to and/or independent of any weight being lost (as weve seen in some of the other uses for these drugs.) They could have tested different doses of the drug to see if people had the effects at lower doses (and thus with fewer dose-dependent side effects.) They didnt

Curr Urol Rep

Nausea runs about 12 percentage points higher

Glutathione occurs in two forms to balance redox reactions and thereby to protect the cells from OS

Retatrutide reduced HbA1c (a three-month average of blood sugar) by 1.8% at the 12mg dose in participants with type 2 diabetes