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In a CT26 tumor-bearing mouse model, the nanomedicine prolonged the drug circulation half-life ( phase t/ = 29.2 hours) and achieved a tumor inhibition rate of 85.2%, outperforming the combination of free drugs

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The serum concentrations of TZP/Sema were measured over time following the subcutaneous administration of each treatment by ELISA to assess the pharmacokinetic profiles of each hydrogel-based formulation

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