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Glaucoma has been associated with nevus of Ota
Proteomic and metabolite profiling reveals profound structural and metabolic reorganization of adipocyte mitochondria in obesity
Immune cell trafficking across the blood-brain barrier in the absence and presence of neuroinflammation
In recent works, the study demonstrated that GCH1/ BH4 pathic enzyme dihydrofolate reductase (DHFR) could inhibit ferroptosis by generating BH4, so decrease in DHFR activity reduces BH4 content to enhance lipid peroxidation and sensitizes cells to ferroptosis (Lu et al., 2024), but the detail process is still unknown (Figure 1)
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