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To counteract amyloid fibril formation that occurs with human Amy, a pair of helix-stabilizing mutations (N14E and V17R) were incorporated into Cagri 2

Irace C, De Luca S, Shehaj E, Carallo C, Loprete A, Scavelli F, et al

Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed sulfation factor, which later became known as somatomedin

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Liquid Chromatography-Mass Spectrometry analysis confirms that the observed molecular mass matches the theoretical value of 1419.5 Daltons exactly