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Patients on both therapies often experience synergistic metabolic improvements: testosterone supports muscle preservation and strength during weight loss, while GLP-1 medications accelerate fat loss and improve cardiometabolic markers

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25 Basal insulinGLP-1 RA fixed-ratio combination injectables Two fixed-ratio combination (FRC) products containing a basal insulin and a GLP-1 RA are also available as options for patients being managed on combination injectable therapy ( Table 5 )

Tirzepatide acts through both GIP and GLP-1 receptors

doi: 10.1177/2042018820938305 198 Torres FernandezEDHuffmanAMSyedMRomeroDGYanes CardozoLL