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637 In LHON mice or rats, intravitreal injection of adeno-associated virus (AAV) vectors carrying nuclear-encoded human MT - ND4 genes resulted in the allotopic expression of the wild-type MT-ND4 gene, with subsequent accumulation of mRNA and protein in RGCs and optic nerve axons, successfully importing them into mitochondria
NO also enhances mitochondrial efficiency (more ATP per oxygen molecule) and preferentially directs blood flow to fast-twitch muscle fibers during high-intensity efforts
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