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An earlier 12-week trial in 300 obese adults produced a genuine positive signal the 1 mg daily dosing arm showed a statistically significant 2.8 kg mean weight loss versus 0.8 kg in the placebo group and that result is what justified moving into the larger Phase IIb trial

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That gap is the largest reported in any Phase 3 obesity trial

Birngruber T, Raml R, Gladdines W, Gatschelhofer C, Gander E, Ghosh A, et al