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Retatrutide is also a 39 amino acid modified GIP molecule, but with changes to the amino acid structure to allow for activity at the GCGR site to achieve triple agonist activity at the GLP-1R, GIP-R, & GCGR
A smaller barrel just spreads it over more space
With drugs like Dapagliflozin now available as generics, the NHS is projected to save over 500 million, perhaps allowing those funds to be reinvested into life-saving GLP-1 and GIP therapies
References Thomas, James N., and Victor Fung
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