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It is therefore suggesting that the slight change of relaxation observed in the aorta without endothelium ex vivo might be due to some mechanism unrelated to the direct nitric oxide stimulation which needs further investigation

A C16 palmitic acid chain attached at Lys26 enables reversible albumin binding, extending the half-life to approximately 13 hours and enabling once-daily dosing

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Full names of enzymes and substrates can be found in the supplementary material