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Nature 494 , 256260 (2013)
During the trial, all participants took tirzepatide for 36 weeks and lost an average of 20.9% of their body weight
By acting on the brains appetite centers and slowing the digestive process, GLP-1 and dual agonist medications help patients feel satisfied with smaller meals and make healthier decisions more consistently
However, it is important to highlight that the GBS study used an older version of the SomaScan assay that included a smaller number of proteomic markers (1,297), and that the comparison used 2 year post-GBS data versus the 1-year follow-up data in the STEP trials
Tirzepatide isolates the GIP/GLP-1 combination, while retatrutide adds glucagon on top
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