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First author Plinio Casarotto, a postdoctoral researcher in UH's Neuroscience Center, and coauthors sum up: "The present findings demonstrate that antidepressants bind to TrkB and allosterically increase BDNF signaling, thereby directly linking the effects of antidepressants to neuronal plasticity." "Antidepressant-induced plasticity is utilized by network-specific neuronal activity to guide re-wiring of plastic networks, allowing beneficial re-adaptation of networks abnormally wired during development or by stress (Castrn, 2013)," they conclude

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