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In summary, histologic features of atypical PN, such as sharp demarcation, expansile growth, epidermal effacement, nuclear pleomorphism, and increased mitoses, were found to differ significantly from those of benign PN
This leads to a brighter complexion, more even skin tone, and a visible reduction in dark spots
A history of GERD, hiatal hernia, or esophagitis amplifies the risk considerably
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For animal studies quality assessment was performed using SYRCLEs risk of bias tool ( Results Out of a total of 1436 identified unique records ( Figure 1 ), we excluded 1372 records for not meeting the inclusion criteria based on title or abstract or upon further evaluation of the full text
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