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This treatment effectively reduced astrogliosis, dystrophic microglia, and promoted neurogenesis, demonstrating a potent neuroprotective effect on early DS phenotypic deficits and dementia (Capsoni and Cattaneo 2022)
DOI: 10.1021/ar00009a003 [4] MASAYASU INOUE
Lang E, Zelenak C, Eberhard M, Bissinger R, Rotte A, Ghashghaeinia M, et al
Upon stimulation, astrocytes undergo significant morphological, transcriptional, and functional changes, transitioning into reactive states characterized by either neurotoxic (A1) or neuroprotective (A2) phenotypes
Lampe JW
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