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Costa DL, Diniz JB, Requena G, Joaquim MA, Pittenger C, Bloch MH, et al
(Campone 2013) A large double-blind RCT (n=409) found no benefit of LC for CIPN prevention in breast cancer patients receiving taxanes
The pathophysiology of neuropathic pain varies and includes ectopic activity in damaged nerves or in adjacent nerves, dorsal root ganglion (DRG) or central pathways, and peripheral and central sensitisation involving numerous molecular mechanisms
[1] Mechanistically it works along a single hormonal pathway the amylin system which is what distinguishes it from the multi-receptor incretin agonists it is often compared with
Research shows that after 6 weeks of elevated IGF-1, receptor density decreases by 40-60%, significantly blunting the peptide's effectiveness (Yakar et al., 2002)
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