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Material and Methods A systematic review of the literature was carried out according to PRISMA guidelines11 for the conduct of meta-analysis of intervention trials
Most randomized trials were rated as low risk or with some concerns , with very few domains rated as high risk
~25% are hereditary (MEN2), 75% sporadic (no hereditary foundation)
Global DNA hypermethylation is independent of established risk factors and associated with an increased risk of insulin resistance 31
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