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Glutathione is essential for both preventing certain diseases and preserving overall health
10.3390/antiox10091407 12 BreijyehZ.KaramanR
Blood 84(10):161a, 1994
We show (i) that PfGrx-catalyzed redox reactions outcompete uncatalyzed reactions between roGFP2 and GSH or GSSG by several orders of magnitude, (ii) that the PfGrx-catalyzed reduction and oxidation of roGFP2 occur via a mono- and not a dithiol mechanism, and (iii) that the reduction of roGFP2(S 2 ) as a model non-glutathione disulfide substrate most likely involves a rate-limiting glutathionylation in a ternary complex with a GSH molecule that is activated at the 1st glutathione-interaction site of PfGrx
Type of study: non-rct in vitro Number of citations: 15 Year: 2023 Authors: Ying-Yin Zhu, Wuqing Xiao, Wanling Zhong, Chen Xi, Jinhong Ye, Qing Zhang, Huichao Wu, Shouying Du Journal: International journal of pharmaceutics Journal ranking: Q1 Key takeaways: The combined system of Cur-Lips and skin-penetrating peptide TD-1 effectively promotes skin penetration and has great potential for melanoma prevention and treatment
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