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Managing Joint Pain Whilst Taking Retatrutide Management should follow NICE NG226 guidance, prioritising exercise, physiotherapy, and topical NSAIDs

[1] [4] In the type 2 diabetes cohort, retatrutide also produced clinically meaningful weight loss alongside reductions in HbA1c

Recognition of these dual misclassification pathways highlights the need for routine consideration of pancreatic etiology in insulin-requiring diabetes, particularly when accompanied by gastrointestinal symptoms, weight loss, or imaging abnormalities

Serious adverse events were reported in a higher proportion of patients who received tirzepatide compared to semaglutide

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