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Key MOTS-c Research Three landmark studies define what we know about MOTS-c

ZZW-15, an inhibitor of nuclear protein 1 (NUPR1), downregulates SLC7A11 and GPX4 mRNA levels and induces ferroptosis in MiaPaCa-2 cells [70]

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Front Mol Biosci 9 Battaglia AM, Sacco A, Perrotta I, Faniello MC, Scalise M, Torella D, Levi S, Costanzo F, Biamonte F (2022) Iron administration overcomes resistance to erastin-mediated ferroptosis in ovarian cancer cells