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The catch is that this synergy is mostly mechanistic speculation

A systematic review of available evidence concluded that whilst biological plausibility exists and early signals are promising, the quality and quantity of evidence remain insufficient to recommend GLP-1 receptor agonists for dementia prevention or treatment outside of clinical trials

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Evidence established that a MERCS-specific E3 ubiquitin ligase, autocrine motility factor receptor (AMFR), ubiquitinates nascent proteins to activate TBK1 at the contact site (Watanabe et al., 2023)

Youll also want to make sure you stay hydrated and drink plenty of water