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Alternative medication classes should be considered if GLP-1 therapy proves intolerable: SGLT2 inhibitors (such as dapagliflozin, empagliflozin) for type 2 diabetes, which work via a completely different mechanism and rarely cause gastrointestinal side effects DPP-4 inhibitors (such as sitagliptin, linagliptin), which enhance endogenous GLP-1 activity more gently Metformin remains first-line for type 2 diabetes, though it can also cause gastrointestinal side effects Orlistat for weight management, though this also has gastrointestinal side effects of a different nature For weight management specifically, NICE recommends a comprehensive approach including dietary modification, increased physical activity, and behavioural interventions, with or without pharmacotherapy

Semaglutide is an FDA-approved medication that has shown significant effectiveness in weight management

Patients who find the medication to be effective can continue to increase the dosage until they reach the maximum recommended dose, at which point they can continue with the weekly injections for the remaining duration of the treatment

Uncontrolled free-radical damage is a key cause in diseases affecting the brain, including schizophrenia and Alzheimers