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FDA-approved GLP-1 peptides such as semaglutide and tirzepatide bind to the GLP-1 receptor, the same receptor a natural gut hormone uses to reduce hunger, slow digestion, and help regulate blood sugar

Oganesyan V, Damschroder MM, Cook KE, Li Q, Gao C, Wu H, et al

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More recently, fecal human -defensin-2 has been suggested as a marker for intestinal permeability in neonates [174]