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Tesamorelin has the strongest evidence by a wide margin
In clinical trial data, fatigue was reported in around 69% of patients
Despite being discovered first, it received less clinical attention for decades because early research suggested that GIP signaling was impaired in type 2 diabetes, making it seem like an unlikely therapeutic target
Aons research found: Average adherence around 71% Approximately half of users maintained adherence rates above 80% Highly adherent patients experienced better outcomes and slower medical cost growth However, other studies suggest long-term persistence remains a challenge
Most users report significant improvement within 48 weeks as their body adapts to the medication
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