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Nature Reviews Drug Discovery , 11 (2), 141168
Limited clinical validation: Despite decades of research interest, DSIP has not progressed into wide-scale clinical adoption, which raises questions about consistency and reproducibility of effects
That said, a recent literature and patent review confirms it still lacks the comprehensive human clinical studies needed for regulatory approval, meaning its research-use status is unlikely to change soon (Jozwiak 2025)
Initial studies were conducted in animal models and progressed to human clinical observations, with particularly strong work on immune function, longevity markers, and circadian regulation
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