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Additionally, senescent cells produce matrix metalloproteinases (MMPs) and other proteolytic enzymes that disrupt the extracellular matrix, interfering with normal tissue structure and function

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The most significant reductions in the ratio of senescent to non-senescent cells was observed for quercetin, Ku-60019, CX-4945 and TBB (4,5,6,7-tetrabromo-2-azabenzamidazole) (Fig

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