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Next-generation agents include CagriSema (semaglutide + cagrilintide, NDA filed December 2025, showing 22.7% weight loss), retatrutide (triple GIP/GLP-1/glucagon agonist, 28.7% weight loss in Phase 3), and orforglipron (oral non-peptide GLP-1, submitted to FDA)
They change stomach size, hunger signaling, fullness, metabolism, and in some cases the way food and calories are absorbed
Inflammatory mediators like TNF-, prompted by NF-B activation, impede PI3K-AKT signaling, hindering GLUT4 translocation to the cell membrane and diminishing peripheral tissue sensitivity to insulin (Hotamisligil et al., 1996
CtDNA has also emerged as a non-invasive tool to detect minimal residual disease and early detection of recurrence in early stage non-small cell lung cancer (NSCLC) (Tan et al., 2024)
Nutrients, 14 (14), 2831
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