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By modifying the OXM peptide sequence with an amino acid-peptide substitution at position 2 to prevent DPP-4 action, in addition to a cholesterol-peptide conjugate, Pocai and colleagues were the first group to show that synthetic dual-agonists were an effective treatment strategy in an animal model
Semaglutide (GLP-1 mono-agonist) typically delivers around 14.9% loss at 68 weeks in STEP 1, against roughly 22.5% for tirzepatide 15 mg in SURMOUNT-1 [4]
Pen delivers a 2mg dose
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