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Int J Dermatol 44:636640 Huppert J, Closhen D, Croxford A, White R, Kulig P, Pietrowski E, Bechmann I, Becher B, Luhmann HJ, Waisman A, Kuhlmann CR (2010) Cellular mechanisms of IL-17-induced blood-brain barrier disruption

10.1002/ajh.25341 14 HasanN.AhmadW.AlamF.HasanM

GHK suppressed RNA production in 70% of these 54 overexpressed genes, demonstrating powerful regulatory capacity

that is, the GHK-Cu peptide injected in one area of the body (such as the thigh muscles) improved healing at distant body areas (such as the ears)

As such, it is possible that redox-associated extrahepatic mechanisms may contribute to the activation of the hepatic AMPK pathway