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Bach1-induced suppression of angiogenesis is dependent on the BTB domain
Pregnancy/nursing: Not enough safety data in pregnant or breastfeeding women
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Proposed Mechanisms Preventing GABA receptor downregulation Counteracting compensatory NMDA glutamate receptor sensitization Stabilizing benzodiazepine receptor configuration (preventing shift to inverse agonist state) Upregulating GABAergic neurotransmission through pathways distinct from benzodiazepine action itself This tolerance prevention has profound clinical implications
doi: 10.1186/s13148-020-00837-1 296 GilbertWVBellTASchaeningC
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