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Lamprakopoulos, A., Zorzos, I
In clinical trials, which typically involved taking GLP-1s for 68 weeks or more, participants experienced significant weight loss, often exceeding 10-15% of their starting weight
Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction
Phase 3 clinical trials are still underway, coming to a close in May 2026
Sometimes the issue is caloric creep, gradual increases in portion sizes or snack frequency that accumulate without being noticed
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