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The ferroptosis signalling pathway is comprehensive, and in addition to the classical disorders of iron metabolism, the glutathionecysteamineglutathione system and polyunsaturated fatty acid metabolism, an increasing number of signalling pathways, such as nicotinamide adenine dinucleotide phosphate/ferroptosis-inhibitory protein 1 and tetrahydrobiopterin/GPT cycloheximide 1/dihydrofolate reductase, have been identified 51
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Discussion Repurposing clinically used drugs is an important strategy in drug discovery and could reduce cost and development timelines due to prior availability of safety and toxicity information 27,28
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