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In comparison, the region that contains the greatest amount of variability between GST classes is contained in the alpha-2 helix on the C-terminal domain

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An amidated C-terminal tyrosine is not tolerated for high affinity peptide interactions with the CTR in the absence of RAMPs

Additionally, BCL2-inhibitors have been shown to have senolytic effects in some senescent cell models 1,4

It acts as a master biological signal for tissue repair and regeneration, with particular potency in skin stimulating collagen and elastin production, activating antioxidant defenses, and remodeling damaged tissue