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Kidney protective associations were also observed in the group with a BMI of 25 or greater

138,139,140 These transport mechanisms, often coupled with vesicular trafficking and metabolic reprogramming, significantly reduce intracellular drug accumulation, attenuate target engagement and contribute to immune evasion, collectively undermining therapeutic efficacy

Scientists have focused on polypeptide drugs because they tend to need lower doses and induce fewer side effects than other drugs

4) is being assessed in the Phase III ESSENCE trial (NCT04822181)