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The 2025 HM15275 liver transcriptomics data demonstrated that glucagon receptor co-activation suppresses amino acid catabolic pathways relative to tirzepatide, suggesting a potentially more favorable fat-to-lean mass loss ratio in the triple agonist context (Lee et al., 2025)

Additionally, significant flux improvement was seen in ATR-TEs (15.67 g/cm 2 /h) and ATR-TEG (11.67 g/cm 2 /h), respectively, in comparison to the flux of ATR-PG (4.21 g/cm 2 /h)

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